Most colorectal cancers develop through a gradual sequence of polyp growth
Colorectal cancer mortality can be significantly reduced by colonoscopy and colonic polypectomy
19 million colonoscopies are performed in the US each year
Expected incidence of pre-malignant polypoid lesions is around 30%
5 % of colonic polyps are laterally spreading lesions (LSLs)
LSLs larger then 20mm are considered high risk precursors of CRC
5 million polyps are discovered each year, in the US, of which around 300,000 are LSLs
Current Practice
LSLs are diagnosed during routine screening or surveillance colonoscopies
In most cases patient is referred to an expert endoscopists for removal of LSLs
Selection of removal technique requires lesions to be categorized based on location, size, morphology, pit pattern and vascular pattern
Endoscopic Mucosal Resection (EMR), Endoscopic Submucosal Dissection (ESD) and Surgical Therapy are some of the available treatment options for polypectomy
LSL removal is technically demanding, requires highly trained personal and specialized equipment
Operating time can range from 2-5 hours for removal of a single LSL
PLP-33 Formulation
A Novel formula for treatment of LSL Polyps: 'pre' and 'post' polypectomy
Formula demonstrated significant synergistic antitumor effect in pre clinical studies
Preclinical POC validation
Upcoming in-vivo studies
Dossier preparation for submission of Pre-IND meeting request with FDA
